In the global context of increasing colonic diseases, colon specific oral drug delivery
systems have shown promise as an effective therapeutic modality. Herein, we developed a …

An enzyme-responsive colon-specific delivery system was developed based on hollow
mesoporous silica spheres (HMSS) to which biodegradable chitosan (CS) was attached via …

We designed a novel oral colon-specific drug delivery system (OCDDS) using a modification
of mesoporous silica nanoparticle (MSN) surfaces with pH-sensitive trimethylammonium …

Mesoporous silica nanoparticles (MSNs) have ideal characteristics as next generation of
controlled drug delivery systems. In this study, a MSN-based nanocarrier was fabricated and …

Conventional oral drug formulations for colonic diseases require the administration of high
doses of drug to achieve effective drug concentrations at the target site. However, this …

Glycosylated pH-sensitive mesoporous silica nanoparticles (MSNs) of capecitabine (CAP)
were developed for targeting colorectal cancer. The MSNs possessed an average pore …

Oral delivery of protein or peptide drugs confronts several barriers, the intestinal epithelium
and the mucus barrier on the gastrointestinal tract is deemed to be the toughest obstacles …

Functional mesoporous silica particles have attracted growing research interest for
controlled drug delivery in targeted cancer therapy. For the purpose of efficient targeting …

Oral chemotherapy is the preferred route for cancer treatment because it can improve the
efficacy and decrease the side effects. Unfortunately, most anticancer drugs suffered from …

Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH
and enzymes) were prepared through conjugation with a structure modified soy protein …