Pancreatic ductal adenocarcinoma (PDAC) is an extremely malignant disease, which has an
extremely low survival rate of< 9% in the United States. As a new hallmark of cancer …

Simple Summary In this review, we describe arginine's role as a signaling metabolite,
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …

Background Pancreatic cancer is a leading cause of cancer-related deaths in the world with
a 5-year survival rate of less than 6%. Currently, there is no successful therapeutic strategy …

An adequate level of arginine in the tissue microenvironment is essential for T cell activity
and survival. Arginine levels are regulated by the arginine-catabolizing enzyme, arginase …

Argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis, is
expressed in many types of human malignancies. Recent studies showed that ASS1 may …

Arginine availability and activation of arginine-related pathways at cancer sites have
profound effects on the tumor microenvironment, far beyond their well-known role in the …

The significant disparities in metabolism between tumor and normal cells have inspired the
development of metabolism-based anti-tumor therapeutics. Arginine is a semi-essential …

Metabolic reprogramming is an emerging hallmark of tumor cells. In order to survive in the
nutrient-deprived environment, tumor cells rewire their metabolic phenotype to provide …

Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-
ornithine. Increasing number of studies in recent years demonstrate that two mammalian …

Arginine (Arg) deprivation is a promising therapeutic approach for tumors with low
argininosuccinate synthetase 1 (ASS1) expression. However, its efficacy as a single agent …