Intestinal inflammation reduces expression of DRA, a transporter responsible for congenital chloride diarrhea
H Yang, W Jiang, EE Furth, X Wen… - American Journal …, 1998 - journals.physiology.org
The pathogenesis of diarrhea in intestinal inflammatory states is a multifactorial process
involving the effects of inflammatory mediators on epithelial transport function. The effect of …
involving the effects of inflammatory mediators on epithelial transport function. The effect of …
Molecular cloning and promoter analysis of downregulated in adenoma (DRA)
WA Alrefai, X Wen, W Jiang, JP Katz… - American Journal …, 2007 - journals.physiology.org
Downregulated in adenoma (DRA), also referred to as SLC26A3, is an intestinal anion
transporter essential for intestinal chloride absorption. Mutations in DRA result in congenital …
transporter essential for intestinal chloride absorption. Mutations in DRA result in congenital …
Activation of Nuclear Factor− κB by Tumor Necrosis Factor in Intestinal Epithelial Cells and Mouse Intestinal Epithelia Reduces Expression of the Chloride Transporter …
A Kumar, I Chatterjee, T Gujral, A Alakkam, H Coffing… - Gastroenterology, 2017 - Elsevier
Background & Aims Diarrhea associated with inflammatory bowel diseases has been
associated with increased levels of inflammatory cytokines, including tumor necrosis factor …
associated with increased levels of inflammatory cytokines, including tumor necrosis factor …
Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon
MN Asghar, S Priyamvada… - American Journal …, 2016 - journals.physiology.org
Keratins (K) are intermediate filament proteins important in protection from stress. The roles
of keratins in the intestine are not clear, but K8 knockout (K8−/−) mice develop a Th2-type …
of keratins in the intestine are not clear, but K8 knockout (K8−/−) mice develop a Th2-type …
slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon
CW Schweinfest, DD Spyropoulos… - Journal of Biological …, 2006 - ASBMB
Mutations in the SLC26A3 (DRA (down-regulated in adenoma)) gene constitute the
molecular etiology of congenital chloride-losing diarrhea in humans. To ascertain its role in …
molecular etiology of congenital chloride-losing diarrhea in humans. To ascertain its role in …
The congenital chloride diarrhea gene is expressed in seminal vesicle, sweat gland, inflammatory colon epithelium, and in some dysplastic colon cells
S Haila, U Saarialho-Kere… - Histochemistry and cell …, 2000 - Springer
Congenital chloride diarrhea (CLD) is an autosomal recessive disorder of intestinal
electrolyte transportation caused by mutations in the anion transporter protein encoded by …
electrolyte transportation caused by mutations in the anion transporter protein encoded by …
Downregulated in adenoma gene encodes a chloride transporter defective in congenital chloride diarrhea
RH Moseley, P Höglund, GD Wu… - American Journal …, 1999 - journals.physiology.org
Congenital chloride diarrhea (CLD) is a recessively inherited disorder characterized by
massive loss of chloride in stool. We previously identified mutations in the downregulated in …
massive loss of chloride in stool. We previously identified mutations in the downregulated in …
SLC26A3 (DRA) prevents TNF-alpha-induced barrier dysfunction and dextran sulfate sodium-induced acute colitis
X Ding, D Li, M Li, H Wang, Q He, Y Wang, H Yu… - Laboratory …, 2018 - nature.com
SLC26A3 encodes a Cl−/HCO3− ion transporter that is also known as downregulated in
adenoma (DRA) and is involved in HCO3−/mucus formation. The role of DRA in the …
adenoma (DRA) and is involved in HCO3−/mucus formation. The role of DRA in the …
Tumor necrosis factor-α acts reciprocally with solute carrier family 26, member 3,(downregulated-in-adenoma) and reduces its expression, leading to intestinal …
X Ding, D Li, M Li, D Tian, H Yu… - … Journal of Molecular …, 2018 - spandidos-publications.com
Abstract Solute carrier family 26, member 3 (Slc26a3), also termed downregulated-in-
adenoma (DRA) is a member of the Slc26 family of anion transporters and is mutated in …
adenoma (DRA) is a member of the Slc26 family of anion transporters and is mutated in …
Mouse down-regulated in adenoma (DRA) is an intestinal Cl−/HCO3− exchanger and is up-regulated in colon of mice lacking the NHE3 Na+/H+ exchanger
JE Melvin, K Park, L Richardson, PJ Schultheis… - Journal of Biological …, 1999 - ASBMB
Mutations in human DRA cause congenital chloride diarrhea, thereby raising the possibility
that it functions as a Cl−/HCO 3− exchanger. To test this hypothesis we cloned a cDNA …
that it functions as a Cl−/HCO 3− exchanger. To test this hypothesis we cloned a cDNA …