The concept of chemically evolvable replicators is central to abiogenesis. Chemical
evolvability requires three essential components: energy-harvesting mechanisms for …

Darwinian evolution involves the inheritance and selection of variations in reproducing
entities. Selection can be based on, among others, interactions with the environment …

Unravelling how the complexity of living systems can (have) emerge (d) from simple
chemical reactions is one of the grand challenges in contemporary science. Evolving …

Conspectus As the remit of chemistry expands beyond molecules to systems, new synthetic
targets appear on the horizon. Among these, life represents perhaps the ultimate synthetic …

Establishing programmable and self-sustaining replication networks in pools of chemical
reagents is a key challenge in systems chemistry. Self-replicating templates are formed from …

In living systems, the formation of structures relies on balancing kinetic and thermodynamic
influences powered by reversible covalent bond chemistry. Although synthetic efforts have …

Studies of complex systems and emerging properties to mimic biosystems are at the
forefront of chemical research. Dynamic multistep cascades, especially those exhibiting …

Our knowledge regarding the early steps in the formation of evolvable life and what
constitutes the minimal molecular basis of life remains far from complete. The recent …

How life can emerge from inanimate matter is one of the grand questions in science. Self-
replicating molecules are necessary for the transition from chemistry to biology, but they …

The field of supramolecular chemistry and molecular self-assembly has entered a new
phase in which the use of chemical reactions to create out-of-equilibrium molecular …