Previous studies have shown that the regular administration of short acting β-agonists can
be associated with adverse effects on airway caliber and bronchial hyperresponsiveness …

We compared the effect of an inhaled corticosteroid, budesonide, and an inhaled β 2-
agonist, terbutaline, on clinical symptoms, lung function, and airway inflammation in 14 adult …

Background. Tolerance to the direct bronchodilator effects of β2-agonists does not appear to
occur in asthma. However, it is not known whether this is true for the nonbronchodilator …

Adding inhaled long-acting β2-agonists to a low dose of inhaled corticosteroids (ICS),
results in better clinical asthma control than increasing the dose of ICS. However, this …

Previous reports suggest that regular use of beta-agonists does not lead to tolerance to their
bronchodilator effects. However, most studies have been conducted in stable asthma. This …

Background. The presence of airway inflammation even in mild asthma points to the
potential value of antiinflammatory therapy. We compared the effect of an inhaled …

Corticosteroids can have acute effects on airway function and methacholine airway
responsiveness in asthma as early as 6 h after dosing, suggesting there may be an acute …

Inhaled β 2-adrenoceptor agonists (β 2-agonists) are the most commonly used asthma
medications in many Western countries. Minor adverse effects such as palpitations, tremor …

There is a transient rebound increase in bronchial reactivity to histamine and methacholine
following regular treatment with an inhaled beta 2-agonist. We set out to determine whether …

The present study was designed to observe the effects of 8 wk of treatment with formoterol
(Foradil) 24 μ g, budesonide 400 μ g, and matched placebo inhaled twice a day on …