Background Buprenorphine maintenance treatment has been evaluated in randomised
controlled trials against placebo medication, and separately as an alternative to methadone …

Background Managed withdrawal is a necessary step prior to drug‐free treatment or as the
end point of substitution treatment. Objectives To assess the effectiveness of interventions …

Background Opioid dependence is associated with substantial health and social burdens,
and opioid agonist treatment (OAT) is highly effective in improving multiple outcomes for …

Background Opiate dependence is becoming increasingly prevalent, with associated
increases in the spread of infectious disease (eg HIV, hepatitis B and C) and overdose …

Aims To compare long‐term outcomes among participants randomized to buprenorphine or
methadone. Design, Setting and Participants Follow‐up was conducted in 2011–14 of 1080 …

Aims To assess the efficacy of buprenorphine compared with methadone maintenance
therapy for opioid dependence in a large sample using a flexible dosing regime and the …

Background Managed withdrawal is a necessary step prior to drug‐free treatment or as the
endpoint of substitution treatment. Objectives To assess the effects of buprenorphine versus …

Maintenance therapy with methadone or buprenorphine‐based regimens reduces opioid
dependence and associated harms. The perception that methadone is more effective than …

Objective Buprenorphine maintenance treatment (BMT) and methadone maintenance
treatment (MMT) are pharmacological treatment programs for individuals with opioid use …

Background Methadone maintenance was the first widely used opioid replacement therapy
to treat heroin dependence, and it remains the best‐researched treatment for this problem …