Background & Aims Many patients with inflammatory bowel diseases (IBD) have ongoing
bowel symptoms of diarrhea or abdominal pain despite mucosal healing. We investigated …

The pathogenesis of inflammatory bowel disease (IBD) is multifactorial with data suggesting
the role of a disturbed interaction between the gut and the intestinal microbiota. A defective …

Background & Aims: Prediction of relapse of inflammatory bowel disease has important
implications for therapeutic stategies. We assessed whether measurement of intestinal …

Objective To determine the role of colonic barrier defects and low-grade inflammation in
irritable bowel syndrome (IBS)-like symptoms in quiescent inflammatory bowel disease …

Background: Trials of maintenance therapy in quiescent Crohn disease are often
underpowered and there is need for objective markers that predict relapse. Intestinal …

Crohn's disease (CD), characterized by discontinuous intestinal injury and inflammation, has
been associated with changes in luminal microbial composition and impaired barrier …

Background Barrier dysfunction is recognized as a pathogenic factor in ulcerative colitis
(UC) and irritable bowel syndrome (IBS), but it is unclear to what extent the factors related to …

Background Increased cell shedding with gap formation and local barrier dysfunction can be
identified endomicroscopically in the terminal ileum of patients with inflammatory bowel …

Background & Aims Increased intestinal permeability has been associated with Crohn's
disease (CD), but it is not clear whether it is a cause or result of the disease. We performed a …

UC and Crohn's disease are characterized by the presence of gut inflammation
accompanied by areas of ulceration (Fig. 1). Mucosal healing is becoming increasingly …