ALKBH5‐Mediated RNA m6A Methylation Regulates the Migration, Invasion, and Proliferation of Rheumatoid Fibroblast‐Like Synoviocytes
Y Kuang, R Li, J Wang, S Xu, Q Qiu, S Lin… - Arthritis & …, 2024 - Wiley Online Library
Objective Fibroblast‐like synoviocytes (FLSs) are critical for promoting joint damage in
rheumatoid arthritis (RA). N 6‐methyladenosine (m6A) modification plays key roles in …
rheumatoid arthritis (RA). N 6‐methyladenosine (m6A) modification plays key roles in …
Decreased ALKBH5, FTO, and YTHDF2 in Peripheral Blood Are as Risk Factors for Rheumatoid Arthritis
Q Luo, Y Gao, L Zhang, J Rao, Y Guo… - BioMed Research …, 2020 - Wiley Online Library
ALKBH5 (alkylation repair homolog protein 5), FTO (fat mass and obesity‐associated
protein), and RNA N6‐methyladenosine (m6A) demethylase, are essential for the m6A …
protein), and RNA N6‐methyladenosine (m6A) demethylase, are essential for the m6A …
METTL3 promotes activation and inflammation of FLSs through the NF-κB signaling pathway in rheumatoid arthritis
W Shi, Y Zheng, S Luo, X Li, Y Zhang, X Meng… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA), a common autoimmune disease, is extremely damaging to
human health. Fibroblast-like synoviocytes (FLSs) have a vital role in the occurrence and …
human health. Fibroblast-like synoviocytes (FLSs) have a vital role in the occurrence and …
Transcriptome-wide high-throughput m6A sequencing of differential m6A methylation patterns in the human rheumatoid arthritis fibroblast-like synoviocytes cell line …
H Jiang, K Cao, C Fan, X Cui, Y Ma… - Journal of Inflammation …, 2021 - Taylor & Francis
Introduction: N6-methyladenosine (m6A) is the most frequent internal modification in
eukaryotic mRNAs and is closely related to the occurrence and development of many …
eukaryotic mRNAs and is closely related to the occurrence and development of many …
Inhibition of Histone H3 Lysine-27 Demethylase Activity Relieves Rheumatoid Arthritis Symptoms via Repression of IL6 Transcription in Macrophages
Z Zhao, Y Zhang, D Gao, Y Zhang, W Han… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) occurs in about 5 per 1,000 people and can lead to severe joint
damage and disability. However, the knowledge of pathogenesis and treatment for RA …
damage and disability. However, the knowledge of pathogenesis and treatment for RA …
N6-methyladenosine (m6A) methyltransferase METTL3-mediated LINC00680 accelerates osteoarthritis through m6A/SIRT1 manner
J Ren, Y Li, S Wuermanbieke, S Hu, G Huang - Cell Death Discovery, 2022 - nature.com
Increasing evidence suggest the biological roles of N6-methyladenosine (m6A) and long
noncoding RNAs (lncRNAs) in the bone disease, especially osteoarthritis (OA). However …
noncoding RNAs (lncRNAs) in the bone disease, especially osteoarthritis (OA). However …
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m6A modification
Y He, W Wang, X Xu, B Yang, X Yu, Y Wu, J Wang - Bone, 2022 - Elsevier
Abstract N 6-methyladenosine (m 6 A) methylation is one of the most common internal
modifications in eukaryotic messenger RNA occurring on N 6 nitrogen of adenosine …
modifications in eukaryotic messenger RNA occurring on N 6 nitrogen of adenosine …
Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast‐like synoviocytes in rheumatoid arthritis
D Chen, S Zeng, M Huang, H Xu… - Journal of cellular …, 2017 - Wiley Online Library
To probe the role of protein arginine methyltransferase 5 (PRMT 5) in regulating
inflammation, cell proliferation, migration and invasion of fibroblast‐like synoviocytes (FLS s) …
inflammation, cell proliferation, migration and invasion of fibroblast‐like synoviocytes (FLS s) …
m6A regulator-mediated RNA methylation modification patterns regulate the immune microenvironment in osteoarthritis
Y Duan, C Yu, M Yan, Y Ouyang, S Ni - Frontiers in Genetics, 2022 - frontiersin.org
Epigenetic regulation, particularly RNA n6 methyl adenosine (m6A) modification, plays an
important role in the immune response. However, the regulatory role of m6A in the immune …
important role in the immune response. However, the regulatory role of m6A in the immune …
Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages
Y Lu, H Zhang, H Pan, Z Zhang, H Zeng, H Xie… - Journal of Translational …, 2023 - Springer
Background Disruption of N6 methyl adenosine (m6A) modulation hampers gene
expression and cellular functions, leading to various illnesses. However, the role of m6A …
expression and cellular functions, leading to various illnesses. However, the role of m6A …