The presence and aggregation of misfolded proteins has deleterious effects in the nervous
system. Among the various diseases caused by misfolded proteins is the family of the …

Polyglutamine (polyQ) diseases are associated with a CAG/polyQ expansion mutation in
unrelated proteins. Upon elongation of the glutamine tract, disease proteins aggregate …

Polyglutamine/poly (Q) diseases are a group nine hereditary neurodegenerative disorders
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …

Polyglutamine diseases are autosomal dominant, late-onset neurodegenerative disorders.
Expansion of a polyglutamine (polyQ) tract above a threshold size leads to misfolding and …

Protein aggregation is a key mechanism involved in neurodegeneration associated with
Alzheimer's, Parkinson's and Huntington's diseases. Nine diseases (including Huntington's) …

Protein misfolding is the molecular basis for several human diseases. How the primary
amino acid sequence triggers misfolding and determines the benign or toxic character of the …

The polyglutamine (polyQ) diseases, such as Huntington's disease and several types of
spinocerebellar ataxias, are a group of inherited neurodegenerative diseases that are …

Polyglutamine diseases comprise a class of familial neurodegenerative disorders caused by
expression of proteins containing expanded polyglutamine tracts. Great progress has been …

The polyglutamine (polyQ) diseases are a class of inherited neurodegenerative diseases
including Huntington's disease, caused by the expansion of a polyQ stretch within each …

The formation of insoluble protein aggregates in neurons is a hallmark of neurodegenerative
diseases caused by proteins with expanded polyglutamine (polyQ) repeats. However, the …