Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

The common technique of growing cells in two-dimensions (2-D) is gradually being replaced
by culturing cells on matrices with more appropriate composition and stiffness, or by …

The acceptance of the new paradigm of 3-D cell culture is currently constrained by the lack
of a biocompatible material in the marketplace that offers ease of use, experimental …

In the human body, almost all cells interact with extracellular matrices (ECMs), which have
tissue and organ-specific compositions and architectures. These ECMs not only function as …

Recreating the most critical aspects of the native extracellular matrix (ECM) is fundamental
to understand and control the processes regulating cell fate and cell function. From the ill …

Many crucial cellular processes in our tissues are governed by complex, spatio-temporally
regulated interactions between cells and their extracellular matrix (ECM). These interactions …

The specific microenvironment that cells reside in fundamentally impacts their broader
function in tissues and organs. At its core, this microenvironment is composed of precise …

Most of the anticancer drug candidates entering preclinical trials fail to be approved for
clinical applications. The following are among the main causes of these failures: studying …

Stem cells are defined as unspecialized cells that are capable of long term self‐renewal and
differentiation into specialized cell types. These unique properties make them an attractive …