Synergy between antimicrobial peptides PGLa and Magainin 2 (MAG2) provides an efficient
way to enhance their antimicrobial ability. However, the underlying molecular mechanism of …

The antimicrobial peptides magainin 2 and PGLa, discovered in the skin of the African
clawed frog, Xenopus laevis, exhibit marked synergism [Westerhoff, HV, Zasloff, M., Rosner …

Magainin 2 and PGLa are cationic, amphipathic antimicrobial peptides which when added
as equimolar mixture exhibit a pronounced synergism in both their antibacterial and pore …

Biophysical and structural studies of peptide–lipid interactions, peptide topology and
dynamics have changed our view of how antimicrobial peptides insert and interact with …

We previously speculated that the synergistically enhanced antimicrobial activity of
Magainin 2 and PGLa is related to membrane adhesion, fusion, and further membrane …

Abstract Mixtures of Magainin 2 and PGLa are simulated with 94 nm-sized bilayers
composed of phospholipids and lyso-phospholipids for 3 μs using coarse-grained force …

Abstract PGLa and magainin 2 (MAG2) are amphiphilic α-helical membranolytic peptides
from frog skin with known synergistic antimicrobial activity. By systematically mutating …

Antimicrobial peptides (AMPs) are alternatives to conventional antibiotics against multi-drug
resistant bacteria with low potential for developing microbial resistance. The design of such …

Antimicrobial peptides (AMPs) offer significant hope in the fight against antibiotic resistance.
Operating via a mechanism different from that of antibiotics, they target the microbial …

Antimicrobial peptide magainin 2 forms pores in lipid membranes and induces membrane
permeation of the cellular contents. Although this permeation is likely the main cause of its …