Background Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion
channel expressed on the mucosal surface of epithelial cells lining several tissues including …

The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel inhabits
the apical membrane of airway epithelia, where its function is essential for mucus hydration …

The airway epithelium is exposed to a variety of air pollutants, which have been associated
with the onset and worsening of respiratory diseases. These air pollutants can vary …

Air pollution stimulates airway epithelial secretion through a cholinergic reflex that is
unaffected in cystic fibrosis (CF), yet a strong correlation is observed between passive …

Acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction may
contribute to chronic obstructive pulmonary disease pathogenesis and is a potential …

Genetic and acquired loss-of-function defect of the cystic fibrosis transmembrane
conductance regulator (CFTR) compromise airway surface liquid homeostasis and …

To maintain health and function in response to inhaled environmental irritants and toxins,
the lungs and airways depend upon an innate defense system that involves the secretion of …

Mucus abnormalities play important roles in the development and/or evolution of most, if not
all, airway diseases. The airway mucus is both a crucial component of the airway's …

The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is a chloride channel
that resides in the apical membrane of airway epithelial cells. Decreased CFTR expression …

Cigarette smoke (CS) exposure induces mucus obstruction and the development of chronic
bronchitis (CB). While many of these responses are determined genetically, little is known …