Decidual Angiogenesis and Placental Orientation Are Altered in Mice Heterozygous for a Dominant Loss-of-Function Gja1 (Connexin43) Mutation

E Winterhager, A Gellhaus, SM Blois… - Biology of …, 2013 - academic.oup.com
Abstract Connexin43 (CX43), encoded by Gja1 in the mouse, is highly expressed in
decidual cells and is known to be important for the transformation of stromal cells into the …

A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse

D Tong, X Lu, HX Wang, I Plante, E Lui… - Biology of …, 2009 - academic.oup.com
Expression of GJA1 (commonly known as connexin43 or Cx43), a major myometrial gap
junction protein, is upregulated before the onset of delivery, suggesting an essential role for …

Connexin43 is expressed in mouse fetal ovary

EM Pérez‐Armendariz, JC Sáez… - … Record Part A …, 2003 - Wiley Online Library
Developmental studies have shown that connexin43 (Cx43) is expressed in the ovary from
the first day of life and throughout the rest of postnatal development. In both mouse …

Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia

D Tong, D Colley, R Thoo, TY Li… - Disease Models & …, 2009 - journals.biologists.com
The essential role of connexin43 (Cx43) during oogenesis has been demonstrated by the
severe germ cell deficiency and arrested folliculogenesis observed in Cx43 knockout mice …

[HTML][HTML] Characterization of connexin31. 1-deficient mice reveals impaired placental development

Q Zheng-Fischhöfer, M Kibschull, M Schnichels… - Developmental …, 2007 - Elsevier
The gap junction gene Connexin31. 1 has been reported to be expressed predominantly in
the epidermis of murine skin. To study the function of this gene, we generated mice in which …

[HTML][HTML] Connexin31-deficient trophoblast stem cells: a model to analyze the role of gap junction communication in mouse placental development

M Kibschull, M Nassiry, C Dunk, A Gellhaus… - Developmental …, 2004 - Elsevier
The connexin (Cx) expression during placental development in rodents is subject to
exacting spatiotemporal regulation. Following implantation, Cx31 characterizes the early …

Analogous and unique functions of connexins in mouse and human placental development

M Kibschull, A Gellhaus, E Winterhager - Placenta, 2008 - Elsevier
Here, we review the expression, localization and the possible role of the different connexin
isoforms in placental function and development in mice and men. Connexin gene deletion in …

Connexin31.1 (Gjb5) Deficiency Blocks Trophoblast Stem Cell Differentiation and Delays Placental Development

M Kibschull, K Colaco, E Matysiak-Zablocki… - Stem Cells and …, 2014 - liebertpub.com
The gap junction channel forming connexins (Cx) Cx31 (Gjb3) and Cx31. 1 (Gjb5) are co-
expressed in the mouse trophoblast lineage. Inactivation of either gene results in partial …

Gap junction connexins in female reproductive organs: implications for women's reproductive health

E Winterhager, GM Kidder - Human reproduction update, 2015 - academic.oup.com
BACKGROUND Connexins comprise a family of∼ 20 proteins that form intercellular
membrane channels (gap junction channels) providing a direct route for metabolites and …

Connexin31-deficiency in mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation

A Plum, E Winterhager, J Pesch, J Lautermann… - Developmental …, 2001 - Elsevier
Mutations in the human GJB3 gene that codes for Connexin31 (Cx31), a protein subunit of
gap junction channels, have recently been reported to cause deafness and the skin disorder …