More than any other cytokine family, the IL-1 family of ligands and receptors is primarily
associated with acute and chronic inflammation. The cytosolic segment of each IL-1 receptor …

Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-
inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in …

Abstract Interleukin (IL)-1, first described∼ 35 years ago as a secreted product of monocytes
and neutrophils, refers to IL-1α and IL-1β, two key cytokines in the activation of innate …

More than any other cytokine family, the interleukin (IL)-1 family is closely linked to the
innate immune response. This linkage became evident upon the discovery that the …

The interleukin (IL) 1 family of cytokines is noteworthy to have pleiotropic functions in
inflammation and acquired immunity. Over the last decades, several progresses have been …

More than any other family, the IL-1 Family of 11 cytokines and 10 receptors provides the
host with an endogenous innate immune system, whereas the family of Toll-like Receptors …

The incidence and diversity of chronic inflammatory diseases is increasing worldwide.
However, the complexity of clinical symptoms has made it difficult to develop therapies that …

Interleukin-I (IL-1) is the prototypic pro-inflammatory cytokine. There are two forms of IL-1, IL-
1α and IL-Iβ and in most studies, their biological activities are indistinguishable. IL-1 affects …

Interleukin-1 is a highly active proinflammatory cytokine that causes not only fever, anorexia,
and other constitutional symptoms but also tissue damage and remodeling. All these effects …

This issue of Seminars in Immunology on The Interleukin-1 (IL-1) Family of Ligands and
Receptors updates the rapidly expanding importance of this family. There are individual …