Background Diabetes mellitus (DM) and hypertension (HTN) are accused of being
responsible for the development of the cardiac fibrosis due to severe cardiomyopathy …

Purpose: This study was designed to investigate the effect of losartan on the myocardial
interstitial fibrosis in diabetic cardiomyopathy (DCM) rats. Methods: In this study, a total of 48 …

Receptor for advanced glycation end products (RAGE) and connective tissue growth factor
(CTGF) play a key role in diabetic myocardial fibrosis, and peroxisome proliferator-activated …

Background Despite the known risk of diabetes-induced cardiac fibrosis, less is known
about whether diabetes causes an altered cardiac phenotype independent of coronary …

Objective: To investigate the effects of ibuprofen on cardiac fibrosis in a rat model of type 1
diabetes. Methods: The diabetic model was established by injecting streptozotocin into the …

Background Diabetic myocardiopathy is characterized by myocardial interstitial fibrosis and
cardiac dysfunction. Statins were found to exert protective effects on cardiovascular disease …

Background Diabetic cardiomyopathy (DCM) contributes to cardiac failure in diabetic
patients. It is characterized by excessive lipids accumulation, with increased triacylglycerol …

OBJECTIVE—Cardiac fibrosis is an important component of diabetic cardiomyopathy.
Peroxisome proliferator–activated receptor γ (PPARγ) ligands repress proinflammatory gene …

BACKGROUND: Human obesity has been associated with alterations of vascular structure,
especially in large and medium arteries, but the effects of insulin-sensitizers are not well …

Objective: To study the effect of blood glucose variability on cardiac fibrosis and its
mechanism in a model of diabetic cardiomyopathy. Methods: A total of 45 Sprague Dawley …