[HTML][HTML] The amyloid-β pathway in Alzheimer's disease
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …
Emerging pathways driving early synaptic pathology in Alzheimer's disease
CA Briggs, S Chakroborty, GE Stutzmann - Biochemical and biophysical …, 2017 - Elsevier
The current state of the AD research field is highly dynamic is some respects, while
seemingly stagnant in others. Regarding the former, our current lack of understanding of …
seemingly stagnant in others. Regarding the former, our current lack of understanding of …
[HTML][HTML] Challenges for Alzheimer's disease therapy: insights from novel mechanisms beyond memory defects
Alzheimer's disease (AD), the most common form of dementia in late life, will become even
more prevalent by midcentury, constituting a major global health concern with huge …
more prevalent by midcentury, constituting a major global health concern with huge …
Biological markers of amyloid β-related mechanisms in Alzheimer's disease
Recent research progress has given detailed knowledge on the molecular pathogenesis of
Alzheimer's disease (AD), which has been translated into an intense, ongoing development …
Alzheimer's disease (AD), which has been translated into an intense, ongoing development …
Aspects of β-amyloid as a biomarker for Alzheimer's disease
U Andreasson, E Portelius, ME Andersson, K Blennow… - 2007 - Taylor & Francis
Alzheimer's disease is an age-related neurodegenerative disorder that results in
progressive cognitive impairment and death. The accumulation of β-amyloid (Aβ) in specific …
progressive cognitive impairment and death. The accumulation of β-amyloid (Aβ) in specific …
[HTML][HTML] An insight into cellular and molecular mechanisms underlying the pathogenesis of neurodegeneration in Alzheimer's disease
Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …
[HTML][HTML] Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease
K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …
neurodegenerative disorder associated with cognition, memory and behavioural …
Amyloid β-interacting partners in Alzheimer's disease: from accomplices to possible therapeutic targets
SH Han, JC Park, I Mook-Jung - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease (AD) is one of the most devastating neurodegenerative diseases in
modern society because of insurmountable difficulties in early diagnosis and lack of …
modern society because of insurmountable difficulties in early diagnosis and lack of …
[HTML][HTML] Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future
Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …
A systemic view of Alzheimer disease—insights from amyloid-β metabolism beyond the brain
J Wang, BJ Gu, CL Masters, YJ Wang - Nature reviews neurology, 2017 - nature.com
Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …
existing treatments for AD produce only a modest amelioration of symptoms. Research into …