The rapid proliferation of cancer cells combined with deficient vessels cause regions of
nutrient and O2 deprivation in solid tumors. Some cancer cells can adapt to these extreme …

Purpose Hypoxia is a condition of insufficient oxygen to support metabolism which occurs
when the vascular supply is interrupted, or when a tumour outgrows its vascular supply. It is …

PURPOSE: Tumor hypoxia plays a fundamental role in tumor progression and treatment
resistance. Recent evidence that hypoxia also influences the regulation and transcription of …

There is a need to measure tumor hypoxia in assessing the aggressiveness of tumor and
predicting the outcome of therapy. A number of invasive and noninvasive techniques have …

There is an important and strong, but complex influence of the tumor microenvironment on
tumor cells׳ phenotype, aggressiveness, and treatment sensitivity. One of the most frequent …

Data from 125 studies describing the pretreatment oxygenation status as measured in the
clinical setting using the computerized Eppendorf pO2 histography system have been …

Tumor hypoxia is a persistent obstacle for traditional therapies in solid tumors. Strategies for
mitigating the effects of hypoxic tumor cells have been developed under the assumption that …

Background: Tumor initiation, growth and relapse after therapy are thought to be driven by a
population of cells with stem cell characteristics, named cancer stem cells (CSC). The …

Hypoxia was identified as a microenvironmental component of solid tumours over 60 years
ago and was immediately recognised as a potential barrier to therapy through the reliance of …

Significance: Most solid tumors contain regions of low oxygenation or hypoxia. Tumor
hypoxia has been associated with a poor clinical outcome and plays a critical role in tumor …