[HTML][HTML] Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88

H Makkawi, S Hoch, E Burns, K Hosur… - Frontiers in cellular …, 2017 - frontiersin.org
Porphyromonas gingivalis is a gram-negative anaerobic periodontal pathogen that persists
in dysbiotic mixed-species biofilms alongside a dense inflammatory infiltrate of neutrophils …

[HTML][HTML] Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss

G Papadopoulos, EO Weinberg, P Massari… - The Journal of …, 2013 - journals.aai.org
Porphyromonas gingivalis is a primary etiological agent of chronic periodontal disease, an
infection-driven chronic inflammatory disease that leads to the resorption of tooth-supporting …

Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced …

E Burns, G Bachrach, L Shapira… - The Journal of …, 2006 - journals.aai.org
Periodontitis is a chronic inflammatory disease that leads to destruction of the attachment
apparatus of the teeth. The presence of particular oral bacteria and the host inflammatory …

TLR2-dependent inflammatory response to Porphyromonas gingivalis is MyD88 independent, whereas MyD88 is required to clear infection

E Burns, T Eliyahu, S Uematsu, S Akira… - The journal of …, 2010 - journals.aai.org
Porphyromonas gingivalis is a Gram-negative anaerobe considered to be a major
periodontal pathogen. TLR2 plays a central role in the response to P. gingivalis infection in …

[HTML][HTML] Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis

T Maekawa, JL Krauss, T Abe, R Jotwani… - Cell host & …, 2014 - cell.com
Certain low-abundance bacterial species, such as the periodontitis-associated oral
bacterium Porphyromonas gingivalis, can subvert host immunity to remodel a normally …

Porphyromonas gingivalis exacerbates ligature-induced, RANKL-dependent alveolar bone resorption via differential regulation of Toll-like receptor 2 (TLR2) and …

J Lin, L Bi, X Yu, T Kawai, MA Taubman… - Infection and …, 2014 - Am Soc Microbiol
Toll-like receptors (TLRs) play a key role in the innate immune responses to periodontal
pathogens in periodontal disease. The present study was performed to determine the roles …

Toll-like receptor 9-mediated inflammation triggers alveolar bone loss in experimental murine periodontitis

PD Kim, X Xia-Juan, KE Crump, T Abe… - Infection and …, 2015 - Am Soc Microbiol
Chronic periodontitis is a local inflammatory disease induced by a dysbiotic microbiota and
leading to destruction of the tooth-supporting structures. Microbial nucleic acids are …

Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1β secretion

AC Morandini, ES Ramos-Junior, J Potempa… - Journal of innate …, 2014 - karger.com
Porphyromonas gingivalis is a major contributor to the pathogenesis of periodontitis, an
infection-driven inflammatory disease that leads to bone destruction. This pathogen …

[HTML][HTML] TLR2 Activation by Porphyromonas gingivalis Requires Both PPAD Activity and Fimbriae

A Wielento, GP Bereta, KB Łagosz-Ćwik… - Frontiers in …, 2022 - frontiersin.org
Porphyromonas gingivalis, a keystone oral pathogen implicated in development and
progression of periodontitis, may also contribute to the pathogenicity of diseases such as …

[HTML][HTML] TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-κB

P Zhang, J Liu, Q Xu, G Harber, X Feng… - Journal of Biological …, 2011 - ASBMB
Osteolytic diseases, including rheumatoid arthritis, osteomyelitis, and periodontitis, are
usually associated with bacterial infections. However, the precise mechanisms by which …