The resurgent landscape of xenotransplantation of pig organs in nonhuman primates

X Zhang, Q Wang, J Zhao, X Li, W Peng, Z Yang… - Science China Life …, 2021 - Springer
Organ shortage is a major bottleneck in allotransplantation and causes many wait-listed
patients to die or become too sick for transplantation. Genetically engineered pigs have …

Advances in organ and tissue xenotransplantation

A Ali, E Kemter, E Wolf - Annual Review of Animal Biosciences, 2024 - annualreviews.org
End-stage organ failure can result from various preexisting conditions and occurs in patients
of all ages, and organ transplantation remains its only treatment. In recent years, extensive …

Xeno-organ donor pigs with multiple genetic modifications–the more the better?

E Kemter, A Schnieke, K Fischer, PJ Cowan… - Current Opinion in …, 2020 - Elsevier
The number of donated human organs and tissues for patients with terminal organ failure
falls far short of the need. Alternative sources, such as organs and tissues from animals, are …

Xenotransplantation: current status in preclinical research

T Lu, B Yang, R Wang, C Qin - Frontiers in immunology, 2020 - frontiersin.org
The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …

Advance of genetically modified pigs in xeno-transplantation

J Deng, L Yang, Z Wang, H Ouyang, H Yu… - Frontiers in Cell and …, 2022 - frontiersin.org
As the standard of living improves, chronic diseases and end-stage organ failure have been
a regular occurrence in human beings. Organ transplantation has become one of the hopes …

Next steps for the xenotransplantation of pig organs into humans

RA Montgomery, SA Mehta, B Parent, A Griesemer - Nature medicine, 2022 - nature.com
Next steps for the xenotransplantation of pig organs into humans | Nature Medicine Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Xenotransplantation in China: present status

Y Wang, T Lei, L Wei, S Du, L Girani… - …, 2019 - Wiley Online Library
The main obstacle to organ transplantation is the shortage of organs from deceased
individuals. Especially in China, the ratio of patients on the waiting list versus the transplant …

Promising potentials of Tibetan macaques in xenotransplantation

H Zheng, T Liu, T Lei, L Girani, Y Wang… - …, 2019 - Wiley Online Library
Organ transplantation is a crucial medical procedure, as it is often the only treatment for
patients suffering from end‐stage organ failure. Unfortunately, the shortage of donor organs …

Pig-to-Human xenotransplantation: Moving toward organ customization

M Gao, J Zhang, R Wang, G Yang… - Precision Clinical …, 2023 - academic.oup.com
Xenotransplantation is a potentially effective way to address the shortage of organ donors.
The improvements in gene editing technology have accelerated a number of a breakthrough …

Genetic engineering of pigs for xenotransplantation to overcome immune rejection and physiological incompatibilities: the first clinical steps

T Lei, L Chen, K Wang, S Du… - Frontiers in …, 2022 - frontiersin.org
Xenotransplantation has the potential to solve the shortfall of human organ donors.
Genetically modified pigs have been considered as potential animal donors for human …