Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …

Abstract Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …

Hypoxia‐inducible factors (HIF s) are key regulators of the transcriptional response to
hypoxic stress. Three inducible isoforms of HIF are present in mammals. HIF 1α and HIF 2α …

Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays
essential roles in mammalian development, physiology and disease pathogenesis. The HIF …

Adaptation to hypoxia is regulated by hypoxia‐inducible factor 1 (HIF‐1), a heterodimeric
transcription factor consisting of an oxygen‐regulated α subunit and a constitutively …

Hypoxia, or lowered physiological oxygenation, is a component of many diseases. The
response to decreased oxygen tensions is also an essential aspect of normal development …

The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive
hypoxic response when oxygen levels are low. The HIF transcriptional program increases …

Hypoxia causes dramatic changes in the expression profiles of genes that encode glycolytic
enzymes, vascular endothelial growth factors, erythropoietin, and other factors in a tissue …

The heterodimeric hypoxia‐inducible factor (HIF)‐1 is a master transcriptional regulator of
oxygen homeostasis and a possible target for gene therapy of ischemic disease. Although …

Sensing and responding to fluxes in oxygen tension is perhaps the single most important
variable in physiology, and animal tissues have developed a number of essential …