Alterations in the intracellular levels of calcium are a common response to cell death stimuli
in animals and fungi and, particularly, in the Neurospora crassa response to staurosporine …

The model organism Neurospora crassa undergoes programmed cell death when exposed
to staurosporine. Here, we show that staurosporine causes defined changes in cytosolic free …

Staurosporine-induced cell death in Neurospora crassa includes a well defined sequence of
alterations in cytosolic calcium levels, comprising extracellular Ca 2+ influx and mobilization …

A large number of Ca2+-signaling proteins have been previously identified and
characterized in Saccharomyces cerevisiae but relatively few have been discovered in …

In eukaryotes, calcium not only is an essential mineral nutrient but also serves as an
intracellular second messenger that is necessary for many physiological processes …

The eukaryotic calcium/calmodulin-dependent protein phosphatase calcineurin is crucial for
the environmental adaption of fungi. However, the mechanism of coordinate regulation of …

In recent years, the emergence of fungal resistance has become frequent, partly due to the
widespread clinical use of fluconazole, which is minimally toxic and effective in the …

Oomycetes are a family of eukaryotic microbes that superficially resemble fungi, but which
are phylogenetically distinct from them. These organisms cause major global economic …

In the last few decades, the emergence of fungal resistance has become frequent due to the
widespread clinical use of currently available antifungal agents. Coping with resistant fungal …

An analysis of the time-dependent genetic response to the death-inducer staurosporine was
performed in Neurospora crassa by transcriptional profiling. Staurosporine induced two …