Purpose We investigated the global gene expression in a large panel of pancreatic
endocrine tumors (PETs) aimed at identifying new potential targets for therapy and …

Abstract Purpose: Pancreatic endocrine neoplasms (PENs) are rare, mostly well-
differentiated endocrine neoplasms, whose biology has been poorly characterized. Global …

Pancreatic endocrine neoplasms are neoplastic proliferations of islet cells or islet cell
precursors and are capable of secreting a variety of synthetic products, including insulin …

Clinical trials indicate efficacy of drugs inhibiting the mammalian target of rapamycin (mTOR)
in the treatment of gastroenteropancreatic neuroendocrine tumours (GEP-NET); however …

The treatment landscape and biologic understanding of neuroendocrine tumors (NET) has
shifted dramatically in recent years. Recent studies have shown that somatostatin analogues …

Purpose: Pancreatic neuroendocrine tumors (pNETs) are uncommon malignancies noted for
their propensity to metastasize and comparatively favorable prognosis. Although both the …

The intrinsic nature of tumour behaviour (stable vs progressive) and the presence of liver
metastases are key factors in determining the outcome of patients with a pancreatic …

Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

Aims: Using Single-cell RNA sequencing (scRNA-seq), we explored the spatiotemporal
heterogeneity of pancreatic neuroendocrine tumors (pNETs) and the underlying mechanism …

Pancreatic neuroendocrine tumors (PanNETs) are complicated and often deadly
neoplasms. A recent increased understanding of their molecular biology has contributed to …