Work during the last decade has led to a novel hypothesis for a question that is half a
century old: how is the secretory activity of GnRH neurons synchronized to produce episodic …

The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

Neurons in the arcuate nucleus (ARC) that concomitantly express kisspeptin, neurokinin B
(NKB) and dynorphin A are termed KNDy neurons and are likely candidates for the intrinsic …

Although it has been recognized for over 4 decades that episodic GnRH secretion is a key
functional characteristic of the hypothalamic–pituitary–gonadal (HPG) axis, the underlying …

The discovery of episodic luteinizing hormone (LH) secretion in 1970 initiated considerable
effort by reproductive neuroendocrinologists to understand the neural mechanisms …

Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy)
neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin …

Gonadotropin-releasing hormone (GnRH) neurons in the basal forebrain are the final
common pathway through which the brain regulates reproduction. GnRH secretion occurs in …

A subpopulation of neurons located within the arcuate nucleus, colocalizing kisspeptin,
neurokinin B, and dynorphin (Dyn; termed KNDy neurons), represents key mediators of …

The reproductive neuropeptide gonadotropin-releasing hormone (GnRH) has two modes of
secretion. Besides the surge mode, which induces ovulation in females, the pulse mode of …

Kisspeptin neurons in the arcuate nucleus (ARC), which co-express neurokinin B (NKB) and
dynorphin A, are termed KNDy neurons. These neurons are candidates for the intrinsic …