Infectious diseases remain a global threat contributing to excess morbidity and death
annually, with the persistent potential for destabilizing pandemics. Improved understanding …

Infectious diseases are a leading cause of death worldwide. Novel therapeutics are urgently
required to treat multidrug‐resistant organisms such as Mycobacterium tuberculosis and to …

The emergence and global epidemic of antimicrobial resistance (AMR) poses a serious
threat to global public health in recent years. AMR genes are shared between bacterial …

The emergence of antimicrobial-resistant (AMR) bacteria has become one of the most
serious threats to global health, necessitating the development of novel antimicrobial …

Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated
proteins (Cas) are essential genetic elements in many archaeal and bacterial genomes …

The rapid emergence of antibiotic-resistant bacteria and the comparatively limited
development of new antibacterial molecules pose a major threat to modern medicine by …

CRISPR-Cas9 emerged as a powerful and universal technology for genome engineering
with wide-ranging innovative implications across biology and medicine. The technology is …

The development of CRISPR-Cas9 technology has revolutionized our ability to edit DNA
and to modulate expression levels of genes of interest, thus providing powerful tools to …

Prokaryotic CRISPR-Cas loci encode proteins that function as an adaptive immune system
against infectious viruses and plasmids. Immunity is mediated by Cas nucleases and small …

Clustered regularly-interspaced short palindromic repeat (CRISPR) sequences cooperate
with CRISPR-associated (Cas) proteins to form the basis of CRISPR-Cas adaptive immune …