CD 16 surface antigens represent activatory molecules in CD3–16+ NK cells. In order to
target NK cells against relatively NK‐resistant ovarian carcinomas, we used an anti‐CD 16 …

To target T lymphocytes against EGF-R+ tumors, we constructed anti-CD3/anti-EGF-R
bimAbs either by the generation of a hybrid hybridoma (quadroma) or by a chemical cross …

MAbs directed against triggering surface molecules expressed by T lymphocytes (CD3,
TCR, CD2, CD28) or by NK cells (CD2, CD16) are able to induce the functional program of …

We used a nude mouse xenograft tumor model to compare the efficacy of unconjugated
CD19 and CD20 mAbs (IgG2a subclass) in mediating antilymphoma effects. Treatment with …

Freshly isolated untreated NK cells undergo rapid apoptosis and lose their cytotoxic function
upon the addition of F (ab′) 2 fragment of anti-CD16 antibodies. Loss of NK cell cytotoxic …

Abstract OV‐TL 3 and MOvl8 MAbs, due to their restricted specificity, have been successfully
used to visualize ovarian cancer in patients and might therefore be used to develop …

Bispecific antibodies recognizing tumour‐associated antigens and trigger molecules
expressed on immune effector cells have been shown to redirect cytotoxicity of several types …

Natural killer (NK) cells represent a potent subset of lymphocytes for targeting and lysing
tumor cells. In contrast to T lymphocytes, they do not need to be preactivated in vitro …

Two different bispecific hybrid antibodies were established by fusing a hybridoma producing
monoclonal antibody (mAb) against the pancarcinoma antigen KS1/4 with either of the two …

A human monoclonal anti-idiotypic antibody, 105AD7, which mimics a colorectal tumor
associated antigen, 791Tgp72, has been developed. A Phase I trial in advanced colorectal …