Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis
DE Sanford, BA Belt, RZ Panni, A Mayer… - Clinical cancer …, 2013 - AACR
Purpose: To determine the role of the CCL2/CCR2 axis and inflammatory monocytes
(CCR2+/CD14+) as immunotherapeutic targets in the treatment of pancreatic cancer …
(CCR2+/CD14+) as immunotherapeutic targets in the treatment of pancreatic cancer …
Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma
Objective Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited
effective treatment options. An alternative strategy is to target cells, such as tumour …
effective treatment options. An alternative strategy is to target cells, such as tumour …
Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in …
TM Nywening, BA Belt, DR Cullinan, RZ Panni, BJ Han… - Gut, 2018 - gut.bmj.com
Objective Chemokine pathways are co-opted by pancreatic adenocarcinoma (PDAC) to
facilitate myeloid cell recruitment from the bone marrow to establish an immunosuppressive …
facilitate myeloid cell recruitment from the bone marrow to establish an immunosuppressive …
Overall survival in a trial of orally administered CCR2 inhibitor CCX872 in locally advanced/metastatic pancreatic cancer: Correlation with blood monocyte counts.
92 Background: The CCL2-CCR2 signaling axis may facilitate migration of myeloid derived
suppressor cells to pancreatic cancer resulting in an immune suppressive tumor …
suppressor cells to pancreatic cancer resulting in an immune suppressive tumor …
The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity
The aim of this study was to discover whether MCP-1/CCL2, a CC chemokine able to attract
macrophages, is expressed in human pancreatic cancer and how it modulates cancer …
macrophages, is expressed in human pancreatic cancer and how it modulates cancer …
[PDF][PDF] CCL 15 Recruits Suppressive Monocytes to Facilitate Immune Escape and Disease Progression in Hepatocellular Carcinoma
Chemokines play a key role in orchestrating the recruitment and positioning of myeloid cells
within the tumor microenvironment. However, the tropism regulation and functions of these …
within the tumor microenvironment. However, the tropism regulation and functions of these …
CXCR2-dependent accumulation of tumor-associated neutrophils regulates T-cell immunity in pancreatic ductal adenocarcinoma
T Chao, EE Furth, RH Vonderheide - Cancer immunology research, 2016 - AACR
Tumor-associated neutrophils are increasingly recognized for their ability to promote tumor
progression, mediate resistance to therapy, and regulate immunosuppression. Evidence …
progression, mediate resistance to therapy, and regulate immunosuppression. Evidence …
[HTML][HTML] Interferon gamma inhibits CXCL8–CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic …
M Zhang, L Huang, G Ding, H Huang… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Pancreatic cancer (PC) is a common malignancy of the digestive system and is
characterized by poor prognosis and early metastasis. Tumor immune escape plays an …
characterized by poor prognosis and early metastasis. Tumor immune escape plays an …
Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer
JG Grossman, TM Nywening, BA Belt, RZ Panni… - …, 2018 - Taylor & Francis
The tumor microenvironment (TME) represents a significant barrier to creating effective
therapies for metastatic colorectal cancer (mCRC). In several malignancies, bone marrow …
therapies for metastatic colorectal cancer (mCRC). In several malignancies, bone marrow …
Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced …
TM Nywening, A Wang-Gillam, DE Sanford… - The lancet …, 2016 - thelancet.com
Background In pancreatic ductal adenocarcinoma, the CCL2–CCR2 chemokine axis is used
to recruit tumour-associated macrophages for construction of an immunosuppressive tumour …
to recruit tumour-associated macrophages for construction of an immunosuppressive tumour …