Malignant brain tumors remain to be highly fatal illnesses with a bleak outlook, as the
average survival rate for patients after receiving medical treatment is less than two years …

Background: Malignant brain tumor is a highly challenging disease for diagnosis, treatment,
and management. Cytotoxicity, distribution and the ability to cross blood brain barrier are …

The treatment of brain tumors has been predominantly hindered by the limited ability of
drugs to penetrate the blood-brain barrier. However, recent advancements in …

High-grade gliomas are still characterized by a poor prognosis, despite recent advances in
surgical treatment. Chemotherapy is currently practiced after surgery, but its efficacy is …

Malignant gliomas are one of the deadliest forms of brain cancer and despite advancements
in treatment, patient prognosis remains poor, with an average survival of 15 months …

Glioblastoma is one of the most aggressive central nervous system malignancies with high
morbidity and mortality. Current clinical approaches, including surgical resection …

The poor prognosis and rapid recurrence of glioblastoma (GB) are associated to its fast-
growing process and invasive nature, which make difficult the complete removal of the …

Malignant brain cancer treatment is limited by a number of barriers, including the blood–
brain barrier, transport within the brain interstitium, difficulties in delivering therapeutics …

The delivery of therapeutic molecules to the brain remains an unsolved problem to the
researchers due to the existence of the blood–brain barrier (BBB), which halts the entry of …

Translation of novel therapies for brain cancer into clinical practice is of the utmost
importance as primary brain tumors are responsible for more than 200,000 deaths …