Mammalian innate immunity is regulated by pattern-recognition receptors (PRRs) and guard
proteins, which use distinct strategies to detect infections. PRRs detect bacterial molecules …

Highlights•The innate immune system utilizes a set of multiprotein complexes called
inflammasomes that can be triggered during infection.•Inflammasome activation supports …

Inflammasomes are multiprotein signaling complexes that are assembled by cytosolic
sensors upon the detection of infectious or noxious stimuli. These complexes activate …

The innate immune system plays a critical role in defense against microbial infection and
employs germline-encoded pattern recognition receptors to detect broadly conserved …

Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …

Inflammasomes are multi‐protein signaling platforms that upon activation trigger the
maturation of the pro‐inflammatory cytokines, interleukin‐1β (IL‐1β) and IL‐18, and cell …

The inflammasomes are large multi-protein complexes scaffolded by cytosolic pattern
recognition receptors (PRRs) that form an important part of the innate immune system. They …

The immune system of multicellular organisms protects them from harmful microbes. To
establish an infection in the face of host immune responses, pathogens must evolve specific …

Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety
of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate …

Inflammasomes are signalling platforms that sense a diverse range of microbial products
and also a number of stress and damage associated endogenous signals. Inflammasome …