Pain associates both sensory and emotional aversive components, and often leads to
anxiety and depression when it becomes chronic. Here, we characterized, in a mouse …

Background Besides chronic stress, chronic pain is a prevalent determinant for depression.
Changes induced in specific brain regions by sustained pain may alter the processing of …

The anterior cingulate cortex (ACC) is thought to be important for acute pain perception as
well as the development of chronic pain after peripheral nerve injury. Nevertheless, how …

Neuropathic pain is caused by a primary lesion or dysfunction in the nervous system.
Investigations have mainly focused on the spinal mechanisms of neuropathic pain, and less …

Chronic pain is a major medical problem that is resistant to conventional medical
intervention. It also causes emotional changes such as anxiety and fear. Furthermore …

Neuropathic pain caused by peripheral nerve injury is a debilitating neurological condition
of high clinical relevance. On the cellular level, the elevated pain sensitivity is induced by …

Pyramidal neurons in the anterior cingulate cortex (ACC), a prefrontal region involved in
processing the affective components of pain, display hyperexcitability in chronic neuropathic …

The anterior cingulate cortex (ACC) is activated in both acute and chronic pain. In this
Review, we discuss increasing evidence from rodent studies that ACC activation contributes …

Pain is a complex multidimensional experience encompassing sensory-discriminative,
affective-motivational and cognitive-emotional components mediated by different neural …

Pain is a complex experience including sensory-discriminative and emotional-affective
components. Base on the intensity and chronification of pain, pain is divided into …