Reactive oxygen species (ROS), either derived from exogenous sources or overproduced
endogenously, can disrupt the body's antioxidant defenses leading to compromised redox …

Reactive oxygen species (ROS) are products of normal cellular metabolism and are known
to act as second messengers. Under physiological conditions, ROS participate in …

Reactive oxygen species (ROS) are well recognized for playing a dual role as both
deleterious and beneficial species. ROS are products of normal cellular metabolism and …

The lung is a delicate organ with a large surface area that is continuously exposed to the
external environment, and is therefore highly vulnerable to exogenous sources of oxidative …

As aerobic organisms, we are continuously and throughout our lifetime subjected to an
oxidizing atmosphere and, most often, to environmental threats. The lung is the internal …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated
throughout the human body. Enzymatic and nonenzymatic antioxidants detoxify ROS and …

Globally, respiratory diseases are major cause of disability and mortality, and more
alarmingly, it disproportionately affects developing countries, which is largely attributed to …

Inflammation of the human lung is mediated in response to different stimuli (eg, physical,
radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental …

In the intracellular redox state (GSH/GSSG) the cell plays a key role in the regulation and
potentiation of the inflammatory response in lung cells. Glutathione and thioredoxin are the …

There is overwhelming evidence that oxidative stress and oxidative damage play a pivotal
role in the pathogenesis of chronic obstructive pulmonary disease (COPD)(1-3). The …