Differential innervation of direct-and indirect-pathway striatal projection neurons

NR Wall, M De La Parra, EM Callaway, AC Kreitzer - Neuron, 2013 - cell.com
The striatum integrates information from multiple brain regions to shape motor learning. The
two major projection cell types in striatum target different downstream basal ganglia targets …

The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding

C Varin, A Cornil, D Houtteman, P Bonnavion… - Nature …, 2023 - nature.com
The basal ganglia are known to control actions and modulate movements. Neuronal activity
in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral …

Control of basal ganglia output by direct and indirect pathway projection neurons

BS Freeze, AV Kravitz, N Hammack… - Journal of …, 2013 - Soc Neuroscience
The direct and indirect efferent pathways from striatum ultimately reconverge to influence
basal ganglia output nuclei, which in turn regulate behavior via thalamocortical and …

Whole-brain mapping of inputs to projection neurons and cholinergic interneurons in the dorsal striatum

Q Guo, D Wang, X He, Q Feng, R Lin, F Xu, L Fu… - PloS one, 2015 - journals.plos.org
The dorsal striatum integrates inputs from multiple brain areas to coordinate voluntary
movements, associative plasticity, and reinforcement learning. Its projection neurons consist …

Functional roles of neurotransmitters and neuromodulators in the dorsal striatum

J Do, JI Kim, J Bakes, K Lee, BK Kaang - Learning & memory, 2013 - learnmem.cshlp.org
The dorsal striatum, with its functional microcircuits galore, serves as the primary gateway of
the basal ganglia and is known to play a key role in implicit learning. Initially, excitatory …

Distinct roles for motor cortical and thalamic inputs to striatum during motor skill learning and execution

SBE Wolff, R Ko, BP Ölveczky - Science advances, 2022 - science.org
The acquisition and execution of motor skills are mediated by a distributed motor network,
spanning cortical and subcortical brain areas. The sensorimotor striatum is an important cog …

Striatal plasticity and basal ganglia circuit function

AC Kreitzer, RC Malenka - Neuron, 2008 - cell.com
The dorsal striatum, which consists of the caudate and putamen, is the gateway to the basal
ganglia. It receives convergent excitatory afferents from cortex and thalamus and forms the …

Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

SS Bolkan, IR Stone, L Pinto, ZC Ashwood… - Nature …, 2022 - nature.com
A classic view of the striatum holds that activity in direct and indirect pathways oppositely
modulates motor output. Whether this involves direct control of movement, or reflects a …

Interpreting the role of the striatum during multiple phases of motor learning

S Cataldi, AT Stanley, MC Miniaci, D Sulzer - The FEBS journal, 2022 - Wiley Online Library
The synaptic pathways in the striatum are central to basal ganglia functions including motor
control, learning and organization, action selection, acquisition of motor skills, cognitive …

The striatum: where skills and habits meet

AM Graybiel, ST Grafton - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
After more than a century of work concentrating on the motor functions of the basal ganglia,
new ideas have emerged, suggesting that the basal ganglia also have major functions in …