Structure-based mechanisms of 2′ 3′-cGAMP intercellular transport in the cGAS–STING immune pathway
Upon activation by double-stranded DNA (dsDNA), the cytosolic dsDNA sensor cyclic GMP-
AMP synthase (cGAS) synthesizes the diffusible cyclic dinucleotide 2′ 3′-cGAMP (cyclic …
AMP synthase (cGAS) synthesizes the diffusible cyclic dinucleotide 2′ 3′-cGAMP (cyclic …
cGAMP the travelling messenger
HTW Blest, L Chauveau - Frontiers in Immunology, 2023 - frontiersin.org
2'3'-cGAMP is a key molecule in the cGAS-STING pathway. This cyclic dinucleotide is
produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA …
produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA …
Biochemistry, cell biology, and pathophysiology of the innate immune cGAS–cGAMP–STING pathway
In the decade since the discovery of the innate immune cyclic GMP–AMP synthase (cGAS)–
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP
JH Maltbaek, S Cambier, JM Snyder, DB Stetson - Immunity, 2022 - cell.com
The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …
Nonspecific DNA binding of cGAS N terminus promotes cGAS activation
The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) mediates innate immune
responses against invading pathogens, or against self-dsDNA, which causes autoimmune …
responses against invading pathogens, or against self-dsDNA, which causes autoimmune …
Cyclic GMP–AMP as an endogenous second messenger in innate immune signaling by cytosolic DNA
K Kato, H Omura, R Ishitani… - Annual review of …, 2017 - annualreviews.org
The innate immune system functions as the first line of defense against invading bacteria
and viruses. In this context, the cGAS/STING [cyclic guanosine monophosphate (GMP) …
and viruses. In this context, the cGAS/STING [cyclic guanosine monophosphate (GMP) …
The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?
NO Gekara, H Jiang - Science Signaling, 2019 - science.org
Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of
foreign or damaged self-DNA inside the cell and is critical for the outcome of infections …
foreign or damaged self-DNA inside the cell and is critical for the outcome of infections …
The cGAS-STING pathway for DNA sensing
TS Xiao, KA Fitzgerald - Molecular cell, 2013 - cell.com
The nucleotidyl transferase cGAS, its second-messenger product cGAMP, and the cGAMP
sensor STING form the basic mechanism of DNA sensing in the cytoplasm of mammalian …
sensor STING form the basic mechanism of DNA sensing in the cytoplasm of mammalian …
Ancient origin of cGAS-STING reveals mechanism of universal 2′, 3′ cGAMP signaling
PJ Kranzusch, SC Wilson, ASY Lee, JM Berger… - Molecular cell, 2015 - cell.com
In humans, the cGAS-STING immunity pathway signals in response to cytosolic DNA via 2′,
3′ cGAMP, a cyclic dinucleotide (CDN) second messenger containing mixed 2′–5′ and …
3′ cGAMP, a cyclic dinucleotide (CDN) second messenger containing mixed 2′–5′ and …
LRRC8A: C/E heteromeric channels are ubiquitous transporters of cGAMP
Summary Extracellular 2′ 3′-cyclic-GMP-AMP (cGAMP) is an immunotransmitter exported
by diseased cells and imported into host cells to activate the innate immune STING pathway …
by diseased cells and imported into host cells to activate the innate immune STING pathway …