During stress conditions such as heat shock and antibiotic exposure, ribosomes stall on
messenger RNAs, leading to inhibition of protein synthesis. To remobilize ribosomes …

Adverse cellular conditions often lead to nonproductive translational stalling and arrest of
ribosomes on mRNAs. Here, we used fast kinetics and cryo-EM to characterize Escherichia …

In all living cells, the ribosome translates the genetic information carried by messenger
RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein …

HflX is a ubiquitous bacterial GTPase that splits and recycles stressed ribosomes. In addition
to HflX, Listeria monocytogenes contains a second HflX homolog, HflXr. Unlike HflX, HflXr …

Bacterial ribosomes frequently translate to the 3′ end of an mRNA without terminating at an
in-frame stop codon. In all bacteria studied to date, these “nonstop” ribosomes are rescued …

The ribosome-associated GTPase HflX acts as an antiassociation factor upon binding to the
50S ribosomal subunit during heat stress in Escherichia coli. Although HflX is recognized as …

The bacterial hibernating 100S ribosome is a poorly understood form of the dimeric 70S
particle that has been linked to pathogenesis, translational repression, starvation responses …

HflX is a GTP binding protein of unknown function. Based on the presence of the hflX gene
in hflA operon, HflX was believed to be involved in the lytic-lysogenic decision during phage …

Ribosome hibernation is a universal translation stress response found in bacteria as well as
plant plastids. The term was coined almost two decades ago and despite recent insights …

During termination of translation, the nascent peptide is first released from the ribosome,
which must be subsequently disassembled into subunits in a process known as ribosome …