Abstract Coagulation factor XII (FXII, Hageman factor, EC= 3.4. 21.38) is the zymogen of the
serine protease, factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced …

Coagulation factor XII (FXII, Hageman factor) is a plasma protease that in its active form
(FXIIa) initiates the procoagulant and proinflammatory contact system. This name arises from …

Factor XII (FXII), a clotting enzyme that can initiate coagulation in vitro, has long been
considered dispensable for normal blood clotting in vivo because hereditary deficiencies in …

Factor XII (FXII) is a coagulation protein that is essential for surface-activated blood
coagulation tests but whose deficiency is not associated with bleeding. For over forty years …

The plasma coagulation system reacts quickly to limit blood loss from injury sites but also
contributes to vascular thrombosis. In current models of hemostatic balance, normal …

The plasma zymogens factor XII (fXII) and factor XI (fXI) contribute to thrombosis in a variety
of mouse models. These proteins serve a limited role in hemostasis, suggesting that …

Blood coagulation is a highly regulated process involving interactions between platelets,
plasma coagulation factors, and the vessel wall. During coagulation in vivo, fibrin formation …

Hereditary deficiency of factor XII (Hageman factor) or factor XI, plasma proteases that
initiate the intrinsic pathway of coagulation, impairs thrombus formation and provides …

Physiologic hemostasis upon injury involves many plasma proteins in a well-regulated
cascade of proteolytic reactions to form a clot. Deficiency of blood coagulation Factors VIII …

Factor XII is a mysterious plasma protein without a clear physiologic function. It was
identified as a clotting factor, but has no clear role in hemostasis. However, FXII also …