Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with few
pharmacological treatments. Minocycline, a tetracycline derivative that inhibits microglial …

Background Minocycline is a tetracycline derivative that readily crosses the blood brain
barrier and appears to have beneficial effects on neuroinflammation, microglial activation …

Neonatal infection is associated with increased lifetime risk for neuropsychiatric disorders
including anxiety and depression, with evidence showing that dysregulation of the …

Autism spectrum disorder (ASD) is diagnosed by core symptoms including impaired social
communication and the presence of repetitive and stereotypical behaviors. There is also …

Minocycline is a broad-spectrum tetracycline antibiotic with multiple actions, including anti-
inflammatory and neuroprotective effects, that was proposed as novel treatment for several …

Major depressive disorder (MDD) is a chronic, recurring, and potentially life-threatening
illness, which affects over 300 million people worldwide. MDD affects not only the emotional …

Biallelic loss-of-function mutations in Coiled-coil and C2 domain containing 1A (CC2D1A)
cause autosomal recessive intellectual disability, sometimes comorbid with other …

Clinical studies examining the potential of anti-inflammatory agents, specifically of
minocycline, as a treatment for depression has shown promising results. However …

Anxiety disorders are chronic, disabling conditions across the world, and bring a great
burden to individuals and society. Although advances have been made in understanding of …

Rationale The role of glial cells, especially microglia and astrocytes, in neuroinflammation
and cognition has been studied intensively. Lipopolysaccharide (LPS), a commonly used …