Challenges in clinical practice, biological mechanism and prospects of physical ablation therapy for COPD

H Zhu, X Zhou, R Ju, J Leng, J Tian, S Qu, S Tao, Y Lv… - Life Sciences, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) is projected to become the third leading
cause of death globally by 2030. Despite the limited treatment options available for …

Advantages of pulsed electric field ablation for COPD: Excellent killing effect on goblet cells

H Zhu, J Leng, R Ju, S Qu, J Tian, H Leng, S Tao… - …, 2024 - Elsevier
Mucus hypersecretion resulting from excessive proliferation and metaplasia of goblet cells in
the airways is the pathological foundation for Chronic obstructive pulmonary disease …

Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond

KH Benam, M Königshoff… - American Journal of …, 2018 - atsjournals.org
A recent report by the World Health Organization revealed that three of the top five causes of
death in humans globally are lung related (1). At the fourth place, chronic obstructive …

COPD Update 2015: Cell Biology goes Clinic?-Important Research Findings for Clinicians

B Schmeck, L Jerrentrup, R Bals - Pneumologie (Stuttgart, Germany), 2015 - europepmc.org
The COPD is a very common, chronic, non-contagious disease causing high mortality as
well as high socio-economical costs worldwide. Its clinical assessment progressively …

Endoscopic options for moderate COPD, chronic bronchitis, and uncontrolled asthma

FJF Herth, K Kontogianni, J Brock - Seminars in Respiratory …, 2022 - thieme-connect.com
Until now, interventional therapies for patients with chronic obstructive pulmonary disease
have been available in the form of lung volume reduction procedures as end-stage options …

Advances in surgical and mechanical management of chronic obstructive pulmonary disease

BH Lashari, GJ Criner - Medical Clinics, 2022 - medical.theclinics.com
Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality in the
United States, behind cardiovascular and malignant disorders. It is also a common cause of …

COPD: Preclinical models and emerging therapeutic targets

E Barreiro, X Wang, J Tang - Expert Opinion on Therapeutic …, 2019 - Taylor & Francis
Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity
and mortality worldwide. Preclinical models of COPD have recently been developed. In …

Why new biology must be uncovered to advance therapeutic strategies for chronic obstructive pulmonary disease

JMK Nguyen, DN Robinson… - American Journal of …, 2021 - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) is characterized by the destruction of
alveolar tissue (in emphysema) and airway remodeling (leading to chronic bronchitis), which …

Bronchoscopic management of COPD and advances in therapy

B DeMarco, CR MacRosty - Life, 2023 - mdpi.com
Chronic Obstructive Pulmonary Disease (COPD) is a highly prevalent and morbid disease
marked by irreversible structural changes in the lungs. Bronchoscopic therapies have …

The pathogenesis of COPD: lessons learned from in vivo animal models.

M Fujita, Y Nakanishi - … medical journal of experimental and clinical …, 2007 - europepmc.org
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitations, that
are not fully reversible. COPD is a major cause of chronic morbidity and mortality throughout …