While targeting experiments carried out on the genes encoding many cell cycle regulators
have challenged our views of cell cycle control, they also suggest that redundancy might not …

ABSTRACT A significant portion of cellular scientific literature published is dedicated to
describing the cloning, the link to cancer, or the characterization of proteins involved in the …

The discussion on cell proliferation cannot be continued without taking a look at the cell
cycle regulatory machinery. Cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors …

In the past decade, the discovery and characterization of cyclin-dependent kinases (CDKs),
the engine cores of the cell cycle machinery, have advanced our understanding of the cell …

A fundamental aspect of cancer is dysregulated cell cycle control. Unlike normal cells that
only proliferate when compelled to do so by developmental or other mitogenic signals in …

The connections between cancer and the basic machinery of the cell cycle have taken a
surprisingly long time to become apparent. However, the past 2 years has seen a dramatic …

Inactivation of cyclin-dependent kinases (Cdks) and/or cyclins in mice has changed our view
of cell cycle regulation. In general, cells are far more resistant to the loss of Cdks than …

It is 3 years since our minireview on cyclins and cancer (Hunter and Pines, 1991), and in that
time the number of connections between oncogenesis and the components that regulate the …

Tumor cell proliferation is frequently associated with genetic or epigenetic alterations in key
cell cycle molecules that regulate the activity of cyclin-dependent kinases (CDKs). These …

Normal cell cycle progression relies on the cell's ability to translate extracellular signals such
as mitogenic stimuli and intact extracellular matrices in order to efficiently replicate DNA and …