Atherosclerotic plaque forms in regions of the vasculature exposed to disturbed flow. NF-κB
activation by fluid flow, leading to expression of target genes such as E-selectin, ICAM-1 …

Atherosclerotic plaque develops at sites of disturbed flow. We previously showed that flow
activates endothelial cell integrins, which then bind to the subendothelial extracellular matrix …

Atherosclerosis is a progressive disorder of the arterial wall and the underlying cause of
cardiovascular diseases such as heart attack and stroke. Today, atherosclerosis is …

Atherogenesis involves activation of NF-κB in endothelial cells by fluid shear stress.
Because this pathway involves integrins, we investigated the involvement of focal adhesion …

Background In the arterial tree, regions exposed to reduced shear stress (low and/or
disturbed flow) are predisposed to atherogenesis. Fluid flow is a potent stimulus for the …

Atherosclerotic lesions form at distinct sites in the arterial tree, suggesting that hemodynamic
forces influence the initiation of atherogenesis. If NF-κB plays a role in atherogenesis, then …

Regions of the arterial tree exposed to laminar flow, which exerts high shear stress, are
protected from inflammation, endothelial cell (EC) death and atherosclerosis. TNFα activates …

Disturbed blood flow induces inflammatory gene expression in endothelial cells, which
promotes atherosclerosis. Flow stimulates the proinflammatory transcription factor nuclear …

vascular endothelial growth factor receptor 2 [VEGFR2]), vascular endothelial (VE)-cadherin,
G proteins, primary cilium, and ion channels are known to be important for mechanosensing …

The role of vascular cells during inflammation is critical and is of particular importance in
inflammatory diseases, including atherosclerosis, ischemia/reperfusion, and septic shock …