Background Carbapenems are the last line of defence against ever more prevalent MDR
Gram-negative bacteria, but their efficacy is threatened worldwide by bacteria that produce …

The wide spread of multidrug-resistant bacteria, particularly carbapenem-resistant Gram-
negative bacteria (CR-GNB), constitutes a major public health threat worldwide, owing to the …

Research articles describing carbapenemases and their genetic environments in Gram-
negative bacteria were reviewed to determine the molecular epidemiology of …

Molecular confirmation of carbapenemase-producing Enterobacteriaceae (CPE) was
introduced in South Africa (SA) at the end of 2011. We report on the detection of these …

Carbapenemases, with versatile hydrolytic capacity against β-lactams, are now an important
cause of resistance of Gram-negative bacteria. The genes encoding for the acquired …

Introduction Carbapenemases have increasingly been reported in enterobacteriaceae
worldwide. Most carbapenemases are plasmid encoded hence resistance can easily …

The dramatic increase in the prevalence and clinical impact of infections caused by bacteria
producing carbapenemases is a global health concern. Carbapenemase production is …

Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) is a concern in
South Africa and worldwide. It is therefore important that these organisms be accurately …

Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can
be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent …

The emergence and spread of carbapenemase-producing bacteria, that hydolyze most β-
lactams, including carbapenems, are a major concern of public health system worldwide …