Karyotype alterations have emerged as on-target complications from CRISPR-Cas9 genome
editing. However, the events that lead to these karyotypic changes in embryos after Cas9 …

CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the
correction of disease-associated alleles in somatic cells. The use of this approach has also …

CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic
mutations that affect the efficiency and precision of its ability to edit the genome. Reducing …

Genome editing occurs in the context of chromatin, which is heterogeneous in structure and
function across the genome. Chromatin heterogeneity is thought to affect genome editing …

Background CRISPR-Cas9 is a revolutionary genome editing technique that allows for
efficient and directed alterations of the eukaryotic genome. This relatively new technology …

With the advent of efficient, easy-to-use genome editing by CRISPR–Cas9, editing human
embryos is now possible, providing tremendous opportunities to study gene function and …

The CRISPR/Cas9 system is a rapid, simple, and often extremely efficient gene editing
method. This method has been used in a variety of organisms and cell types over the past …

CRISPR–Cas9 is poised to become the gene editing tool of choice in clinical contexts. Thus
far, exploration of Cas9-induced genetic alterations has been limited to the immediate …

The CRISPR/Cas system has revolutionized the field of genome-editing as it is easier, faster,
less expensive, and more efficient than traditional methods. In a very short time, its …

Developmental biologists have become increasingly aware that the wealth of knowledge
generated through genetic studies of pre-implantation mouse development might not easily …