Activation of the intrinsic pathway of coagulation contributes to the pathogenesis of arterial
and venous thrombosis. Critical insights into the involvement of intrinsic pathway factors …

Formation of a fibrin clot is mediated by a group of tightly regulated plasma proteases and
cofactors. While this system is essential for minimizing blood loss from an injured blood …

The classic intrinsic pathway of coagulation is triggered by contact activation of the plasma
protease factor (F) XII, followed by sequential proteolytic activation of FX1 and FIX. While a …

Blood coagulation is a highly regulated process involving interactions between platelets,
plasma coagulation factors, and the vessel wall. During coagulation in vivo, fibrin formation …

The plasma coagulation system reacts quickly to limit blood loss from injury sites but also
contributes to vascular thrombosis. In current models of hemostatic balance, normal …

The dose-limiting issue with available anticoagulant therapies is bleeding. Is there an
approach that could provide antithrombotic protection with reduced bleeding? One …

Cardiovascular disease, including stroke, myocardial infarction, and venous
thromboembolism, is one of the leading causes of morbidity and mortality worldwide …

Although anticoagulation without hemorrhage is a primary aim, this vision has remained as
yet out of reach. Even despite the superior safety profile of the direct oral anticoagulants …

Recent studies indicate that the plasma contact system plays an important role in
thrombosis, despite being dispensable for hemostasis. For example, mice deficient in …

Factor XII (FXII), a clotting enzyme that can initiate coagulation in vitro, has long been
considered dispensable for normal blood clotting in vivo because hereditary deficiencies in …