Telomere shortening is the main molecular mechanism of aging, but not the only one. The
adaptive immune system also ages, and older organisms tend to develop a chronic pro …

Cellular senescence increases with aging and results in secretion of pro-inflammatory
factors that induce local and systemic tissue dysfunction. We conducted the first preclinical …

Clearing senescent cells extends healthspan in mice. Using a hypothesis‐driven
bioinformatics‐based approach, we recently identified pro‐survival pathways in human …

Most age-related diseases and aging itself are associated with chronic inflammation. Thus
pharmacological inhibition of inflammatory processes may be effective antiaging strategy. In …

Low-grade chronic inflammation is a common denominator in atherogenesis and related
diseases. Solid evidence supports the occurrence of an impairment in the innate and …

Senolytics are a class of drugs that selectively remove senescent cells. Dasatinib and
quercetin have been discovered, and their combination has shown various anti-ageing …

Cellular senescence plays a key role in mediating tissue remodeling and modulation of host
responses to pathogenic stimuli. Our current study was designed to gain a better …

In recent years, cellular senescence has become the focus of attention in multiple areas of
biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by …

Accumulating evidence indicates that the increased burden of senescent cells (SCs) in aged
organisms plays an important role in many age-associated diseases. The pharmacological …

Background Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and
represents a growing challenge in terms of prevention and treatment. A minority of affected …