Highlights•Systems biology approaches support drug development efforts.•Models of
angiogenesis aid in testing anti-angiogenic therapeutic strategies.•Models provide novel …

Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …

Vascular endothelial growth factor (VEGF) is a family of cytokines for which the
dysregulation of expression is involved in many diseases; for some, excess VEGF causes …

Tumour angiogenesis allows a growing mass of cancer cells to overcome oxygen diffusion
limitation and to increase cell survival. The growth of capillaries from pre-existing blood …

Angiogenesis is the formation of new blood vessels from preexisting microvessels.
Excessive and insufficient angiogenesis has been associated with many diseases including …

Tumor associated angiogenesis is the development of new blood vessels in response to
proteins secreted by tumor cells. These new blood vessels allow tumors to continue to grow …

This article aims to promote integration of angiogenesis-related models, both integration of
the work described herein and many other existing and future models. Integration of …

Vascular endothelial growth factor (VEGF) is a strong promoter of angiogenesis in tumors,
and anti‐VEGF treatment, such as a humanized antibody to VEGF, is clinically used as a …

The vascular endothelial growth factor receptors (VEGFR) play a significant role in
angiogenesis, the formation of new blood vessels from existing vasculature. Systems …

Signal transduction is part of a complex communication system responsible for regulating
fundamental cellular activities, including metabolism, protein synthesis, division, migration …