New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

N Zisapel - British journal of pharmacology, 2018 - Wiley Online Library
In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the
hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light …

Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists

FW Turek, MU Gillette - Sleep medicine, 2004 - Elsevier
Circadian rhythm sleep disorders (CRSDs), whether chronic or transient, affect a broad
range of individuals, including many elderly, those with severe visual impairments, shift …

Melatonin and sleep in aging population

SR Pandi-Perumal, N Zisapel, V Srinivasan… - Experimental …, 2005 - Elsevier
The neurohormone melatonin is released from the pineal gland in close association with the
light–dark cycle. There is a temporal relationship between the nocturnal rise in melatonin …

Role of the melatonin system in the control of sleep: therapeutic implications

SR Pandi-Perumal, V Srinivasan, DW Spence… - CNS drugs, 2007 - Springer
The circadian rhythm of pineal melatonin secretion, which is controlled by the
suprachiasmatic nucleus (SCN), is reflective of mechanisms that are involved in the control …

Melatonin rhythmicity: effect of age and Alzheimer's disease

DJ Skene, DF Swaab - Experimental gerontology, 2003 - Elsevier
The circadian rhythm of the pineal gland hormone, melatonin is generated within the
hypothalamic suprachiasmatic nuclei (SCN), site of the circadian clock. The circadian clock …

Melatonin receptors: role on sleep and circadian rhythm regulation

ML Dubocovich - Sleep medicine, 2007 - Elsevier
The circadian release of the hormone melatonin is regulated by the suprachiasmatic
nucleus (SCN), which feeds back into the nucleus to modulate sleep and circadian phase …

Role of melatonin in the regulation of human circadian rhythms and sleep

C Cajochen, K Kräuchi… - Journal of …, 2003 - Wiley Online Library
The circadian rhythm of pineal melatonin is the best marker of internal time under low
ambient light levels. The endogenous melatonin rhythm exhibits a close association with the …

Melatonin: Nature's most versatile biological signal?

SR Pandi‐Perumal, V Srinivasan… - The FEBS …, 2006 - Wiley Online Library
Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity
occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including …

Melatonin and human rhythms

J Arendt - Chronobiology international, 2006 - Taylor & Francis
Melatonin signals time of day and time of year in mammals by virtue of its pattern of
secretion, which defines 'biological night.'It is supremely important for research on the …

Melatonin as a chronobiotic

J Arendt, DJ Skene - Sleep medicine reviews, 2005 - Elsevier
Melatonin, hormone of the pineal gland, is concerned with biological timing. It is secreted at
night in all species and in ourselves is thereby associated with sleep, lowered core body …