The glutathione (GSH) system is considered to be one of the most powerful endogenous
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …

Oxidative stress has been shown to induce cell death in a wide range of human diseases
including cardiac ischemia/reperfusion injury, drug induced cardiotoxicity, and heart failure …

Reactive oxygen species (ROS) produced in the ischemic myocardium can induce
cardiomyocyte injury and death, resulting in cardiac remodeling. Ferroptosis, known as a …

Acute myocardial infarction remains the leading cause of death in humans. Timely
restoration of blood perfusion to ischemic myocardium remains the most effective strategy in …

High levels of circulating catecholamines cause cardiac injury, pathological remodeling, and
heart failure, but the underlying mechanisms remain elusive. Here we provide both in vitro …

Cardiovascular diseases, including cardiomyopathy, myocardial infarction, myocardial
ischemia/reperfusion injury, heart failure, vascular injury, stroke, and arrhythmia, are …

Ferroptosis is a newly discovered form of regulated cell death dependent on iron and
reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione …

Ferroptosis is an iron‐dependent form of cell death caused by the inactivation of glutathione
peroxidase 4 (GPX4) and accumulation of lipid peroxides. Ferroptosis has been found to …

Ferroptosis, a newly discovered form of regulated cell death dependent on iron and reactive
oxygen species, is mainly characterized by mitochondrial shrinkage, increased density of …

Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of
lipid peroxides (LOOH) and redox disequilibrium. Ferroptosis shows unique characteristics …