Fibrosis is a pathological process associated with most chronic inflammatory diseases. It is
defined by an excessive deposition of extracellular matrix proteins and can affect nearly …

Intestinal fibrosis is a common complication in inflammatory bowel disease (IBD) without
specific treatment. As macrophages are the key actors in inflammatory responses and the …

Fibrosis is a complex and difficult to elucidate pathological process with no available
therapies. Growing evidence implicates intestinal microbiota in the occurrence and …

In individuals with inflammatory bowel diseases, intestinal fibrosis is a serious clinical
complication with no specific therapies. Patients develop bowel fistulae and strictures that …

Intestinal fibrosis associated stricture is a common complication of inflammatory bowel
disease usually requiring endoscopic or surgical intervention. Effective anti-fibrotic agents …

Gut microbiota refers to the complex aggregation of microbes in gut, including bacteria,
archaea, fungi, and viruses, and they exert marked influence on the host's health …

The rapid development of metagenomics, metabolomics, and metatranscriptomics provides
novel insights into the intestinal microbiota factors linked to inflammatory bowel disease …

Inflammatory bowel disease (IBD) has become a global disease with accelerating incidence
worldwide in the 21st century while its accurate etiology remains unclear. In the past …

The gut microbiota is indispensable for maintaining host health by enhancing the host's
digestive capacity, safeguarding the intestinal epithelial barrier, and preventing pathogen …

In Crohn's disease (CD), intestinal fibrosis is a critical determinant of a patient's prognosis.
Although inflammation may be a prerequisite for the initiation of intestinal fibrosis, research …