The aerosol inhalation delivery of isoniazid in mice was investigated, and the specific activity
of the aerosol form of isoniazid was studied with the mouse model of tuberculosis infection …

Limited data exist on the pharmacokinetic-pharmacodynamic (PK-PD) parameters of the
bactericidal activities of the available antimycobacterial drugs. We report on the PK-PD …

Excipient-free isoniazid aerosol formation and pulmonary delivery in mice are studied. An
evaporation-nucleation route is used for the generation of isoniazid aerosol. Particle …

Here we describe an experimental murine model that allows for aerosolized antituberculosis
drug efficacy testing. Intrapulmonary aerosol delivery of isoniazid, capreomycin, and …

Tuberculosis is a major health problem and remains one of the main causes of mortality. In
recent years, there has been an increased interest in the pulmonary delivery of antibiotics to …

We explored suitability of a rat tuberculosis aerosol infection model for investigating the
pharmacodynamics of new antimycobacterial agents. Infection of rats via the aerosol route …

The study compared antituberculous efficacy of individual or combined administration of
“free” isoniazid and liposomal form of dextrazide (a composition consisted of isoniazid and …

Intracellular concentrations of isoniazid and rifabutin resulting from administration of
inhalable microparticles of these drugs to phorbol-differentiated THP-1 cells and the …

The blood concentration of isoniazid (INH) is evidently affected by polymorphisms in N-
acetyltransferase 2 (NAT2), an enzyme that is primarily responsible for the trimodal (ie, fast …

The main purpose of this study is to develop isoniazid as dry powder aerosol for delivery to
the lower airways and to study the susceptibility of M. bovis and M. tuberculosis to the …