Differentiation of functional thyroid epithelia from pluripotent stem cells (PSCs) holds the
potential for application in regenerative medicine. However, progress toward this goal is …

The in vitro-directed differentiation of pluripotent stem cells (PSCs) through stimulation of
developmental signaling pathways can generate mature somatic cell types for basic …

The thyroid gland captures iodide in order to synthesize hormones that act on almost all
tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid …

Objective: The aim of this study was to assess the impact of transcriptional induction on
thyroid follicular cell (TFC) differentiation from endodermally matured embryonic stem (ES) …

Objective: The molecular events that lead to human thyroid cell speciation remain
incompletely characterized. It has been shown that overexpression of the regulatory …

Human pluripotent stem cells (hPSCs) provide an unlimited cell source for regenerative
medicine. Hormone-producing cells are particularly suitable for cell therapy, and …

The primary function of the thyroid gland is to metabolize iodide by synthesizing thyroid
hormones, which are critical regulators of growth, development and metabolism in almost all …

Summary Two populations of Nkx2-1+ progenitors in the developing foregut endoderm give
rise to the entire postnatal lung and thyroid epithelium, but little is known about these cells …

Advances over the last decade suggest that generating functional β-cells from human PSCs
is achievable. However, there are aspects of β-cell development that are not well …

Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and
negative regulators are indispensable for homeostasis. For this reason, generating human …