To identity fast-acting, multistage antimalarial agents, a series of pyridylvinylquinoline-
triazole analogues have been synthesized via CuAAC. Most of the compounds display …

Abstract Novel 4‐amino‐7‐chloroquinoline‐based 1, 2, 3‐triazole hybrids were synthesised
in good yields by CuI‐catalysed Huisgen 1, 3‐dipolar cycloaddition reactions of 2‐azido‐N …

Malaria is a devastating disease caused by Plasmodium parasites. Emerging resistance
against current antimalarial therapeutics has engendered the need to develop antimalarials …

A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline
and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity …

Plasmodium falciparum, the causative agent of the most lethal form of malaria, is becoming
increasingly resistant to most available drugs. A convenient approach to combat parasite …

There is an urgent need to develop new efficacious antimalarials to address the emerging
drug-resistant clinical cases. Our previous phenotypic screening identified styrylquinoline …

Despite emergence of resistance to CQ and other 4-aminoquinoline drugs in most of the
endemic regions, research findings provide considerable support that there is still significant …

A substantial challenge worldwide is emergent drug resistance in malaria parasites against
approved drugs, such as chloroquine (CQ). To address these unsolved CQ resistance …

A DMAP catalyzed synthesis of new 4-benzyloxy-and 4-aryloxy-2-
trichloromethylquinazolines was studied, in a view to react 4-chloroquinazolines with poorly …

In the search of new antiplasmodial agents, a multitargeted approach was used in the
synthesis of triazolopyrimidine-and 4-aminoquinolines-based hybrids. In vitro antiplasmodial …