The mitochondrion of apicomplexan parasites is critical for parasite survival, although the full
complement of proteins that localize to this organelle has not been defined. Here we …

Apicomplexan parasites constitute more than 6,000 species infecting a wide range of hosts.
These include important pathogens such as those causing malaria and toxoplasmosis. Their …

Mitochondria distribution in cells controls cellular physiology in health and disease. Here we
describe the mitochondrial morphology and positioning found in the different stages of the …

The mitochondrion is critical for the survival of apicomplexan parasites. Several major anti-
parasitic drugs, such as atovaquone and endochin-like quinolones, act through inhibition of …

Apicomplexan parasites cause diseases such as malaria and toxoplasmosis. The
apicomplexan mitochondrion shows striking differences from common model organisms …

The mitochondrial electron transport chain (mETC) and F1Fo-ATP synthase are of central
importance for energy and metabolism in eukaryotic cells. The Apicomplexa, important …

Outside of well characterized model eukaryotes, relatively little is known about the
translocons that transport proteins across the two membranes that surround the …

Upon invasion of host cells, the ubiquitous pathogen Toxoplasma gondii manipulates
several host processes, including re-organization of host organelles, to create a replicative …

To investigate how intracellular parasites manipulate their host cell environment at the
molecular level, we undertook a quantitative proteomic study of cells following infection with …

Toxoplasma gondii is an aerobic protozoan parasite that possesses mitochondrial
antioxidant enzymes to safely dispose of oxygen radicals generated by cellular respiration …